https://www.selleckchem.com/pr....oducts/jnj-42226314.
Cancer-associated fibroblasts (CAFs) play a key role in the cancer process, but the research progress is hampered by the paucity of preclinical models that are essential for mechanistic dissection of cancer cell-CAF interactions. Here, we aimed to establish 3-dimensional (3D) organotypic co-cultures of primary liver tumor-derived organoids with CAFs, and to understand their interactions and the response to treatment. Liver tumor organoids and CAFs were cultured from murine and human primary liver tumors. 3D co-culture models of tum
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