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In polarized T cells, HIV-1 architectural protein Gag localizes to the plasma membrane of uropod, a rear-end protrusion. Particularly, uropod transmembrane proteins PSGL-1 and CD43 cocluster particularly with Gag assembling in the plasma membrane layer even in cells that do not form uropods. Recent reports have indicated that expression of either PSGL-1 or CD43 in virus-producing cells lowers the infectivity of progeny virions and that HIV-1 illness lowers the mobile surface expression among these pro