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Treatment For ADHD The main treatments for add are medication and psychosocial therapy (psychotherapy). The drugs include stimulants such as methylphenidate, amphetamine, and atomoxetine. They may also be non-stimulants like clonidine or Guanfacine. Stimulant medication should not be used in patients who have active substance abuse issues, however they are a possibility for those who are in stable in remission.