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More over, the development inhibitory effectation of substance 10 on MDA-MB-231 cells ended up being associated with mobile cycle arrest and apoptosis. Norhierridin B (1 interfered with several p53 transcriptional goals, increasing p21, Bax, and MDM2, while lowering Bcl-2 necessary protein levels, which proposed the potential activation of a p53 path. Altogether, these results evidenced outstanding enhancement associated with antitumor activity of hydroquinone 10 in comparison with 6 and its own structurally-related quinone (9). Parti
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