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Treatment For ADHD The most effective treatments for add are medication and psychosocial therapy (psychotherapy). include stimulants such as methylphenidate amphetamine and Atomoxetine. They may also be non-stimulants like clonidine or Guanfacine. The use of stimulants are not recommended for patients with active substance abuse problems but they are a possibility for those who are in stable in remission. Combination therapy