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Serum IgG2 levels (2.68 g/L, 2.68-3.53 g/L, 3.54-4.45 g/L); hospital admission in the preceding two years; bacterial colonisation with potentially pathogenic organisms and asthma were independent predictors for three or more bronchiectasis exacerbations. Those with low IgG2 levels (2.68 g/L and 2.68-3.53 g/L), had worsening progression of their bronchiectasis, using the Bronchiectasis Severity Index, over one year compared with those who were IgG2 replete (4.45 g/L))(p = 0.003, 0.013). Reduced IgG2 levels was an independent

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