https://www.selleckchem.com/pr....oducts/gsk2126458.ht
The results showed that BZYQ could attenuate DAI, CMDI, and histological inflammation. TJ proteins expression was decreased in UC rats, but treatment with BZYQ restored the expression of occludin and claudin-1. In addition, BZYQ administration ameliorated UC-associated increase in the production of TNF- , IL-1 , and the expression of TLR4, NF- B, p-NF- B, MLCK, MLC, and p-MLC, while BZYQ administration increased the production of IL-10. The therapeutic effect of BZYQ on UC is at least partially through regulation of the secretion of
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