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These data indicate that even though the Ln(DO2A2MnBu)+ complexes have actually lower thermodynamic stabilities, their particular kinetic inertness should always be enough for in vivo use. Calcium (Ca2+) release-activated Ca2+ (CRAC) stations mediated by STIM1/2 and ORAI (ORAI1-3) proteins form the dominant store-operated Ca2+ entry (SOCE) pathway in a wide variety of cells. Among these, the enamel-forming cells known as ameloblasts count on CRAC station purpose to enable Ca2+ influx, that
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