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The meta-analysis gathered data from 859 patients but was nevertheless not significant (  = 0.12). The TSA confirmed this evidence revealing that it was due to a lack of statistical power since the required information size (RIS) threshold is not reached. The existing evidence revealed that there are not enough data to support the hypothesis that restorations with dental amalgam can cause nephrotoxicity when compared with composite resins restorations. The existing evidence revealed that there are not enough data to support the hypothes

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