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When triggered, vinculin and metavinculin bind F-actin via their five-helix bundle end domains. Unlike vinculin, metavinculin has a 68-amino-acid insertion prior to the second α-helix with this five-helix F-actin-binding domain. Here, we present the full-length cryogenic electron microscopy structure of metavinculin that captures the dynamics of its specific domain names and unveiled a hallmark architectural feature, namely a kinked isoform-specific α-helix in its F-actin-binding domain. Our ide
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