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Our calculated PNS parameters matched experimental measurements to within experimental uncertainty for 73% of ∆G estimates and 80% of SR estimates. Computation time is seconds for initial E-field maps and milliseconds for E-field updates for different gradient designs, allowing for highly efficient iterative optimization of gradient designs and enabling new dimensions in PNS-optimal gradient design. We have developed accurate and computationally efficient methods for prospectively determining PNS limits, with specific application to head

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