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A mathematical model with twin paired oscillators that integrates Ca2+-induced Ca2+ launch in the IP3R and mutual comments mechanisms of cross-coupling between Ca2+ and IP3 reproduces this behavior. Therefore, multiple Ca2+ oscillation modes can coexist in the same cellular, and hormone stimulation can change through the simpler to the more complex to yield robust signaling. Cisplatin (CDDP) is a very successful anticancer drug in disease therapy; nevertheless, its

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