https://www.selleckchem.com/pr....oducts/Flavopiridol.
In 1864, Hugo Schiff, aged 30, discovered the reaction of aromatic aldehydes with primary amines to give imine derivatives. A C═N imine bond presents the unique properties of being strong, as expected for a covalent double bond, and of being reversible due to a fast hydrolytic process. In view of such features, Schiff base condensations are thermodynamically controlled, which, in the case of reactions involving multifunctional aldehydes and primary amines, allow the formation of complex and sophisticated structures through a trial-
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