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tial and therefore in screening of new platinum compounds for low or absent sensitization potential. Additional studies are required to determine whether the DPRA may be successfully applied to other metals. We provide details on method modifications and precautions important to the success of the DPRA in the assessment of metal reactivity. This journal is © The Royal Society of Chemistry 2019.Stiffness following total knee arthroplasty (TKA) can be a devastating complication to the patient by limiting his function. Various causes have be