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Alzheimer's disease has been extensively studied using undirected graphs to represent the correlations of BOLD signals in different anatomical regions through functional magnetic resonance imaging (fMRI). However, there has been relatively little analysis of this kind of data using directed graphs, which potentially offer the potential to capture asymmetries in the interactions between different anatomical brain regions. The detection of these asymmetries is relevant to detect the disease in an early stage. For this reason, in this paper
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