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Furthermore, Caffeine pulsed MSCs caused a significant reduction in the serum levels C-reactive protein, Nitric oxide, Myeloperoxidase, TNF-α and conversely led a significant increase in the levels of IL-10 more prominent than the similar findings brought about by MSCs alone. CONCLUSION In general, caffeine-treated MSCs may be a promising strategy for cell-based therapy of RA. Interest in galactomannans and its derivatives as a functional health supplement is growing based on physicochemical properties. In this work, the optimized condi

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