https://www.selleckchem.com/pr....oducts/bgb-283-bgb28
PTEN induced putative kinase 1 (PINK1)-mediated mitophagy process is tightly associated with various age-dependent diseases in mammals. The roles of miRNAs (miRNAs) in the PINK1-mediated mitophagy process are not fully understood. Here we discovered that miR-34a-5p suppresses PINK1 expression directly though two post-transcriptional non-classical binding modes, resulting in inhibition of PINK1-mediated mitophagy process. For in vivo experiments, brains were dissected from 8weeks old and 40weeks old C57BL/6 male mice to measure mi
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