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The aim of this research was to determine the effects of Met on ferroptosis caused by lipid overburden and also the outcomes of these changes on vascular smooth muscle mass cells (VSMCs) calcification. We developed a hyperlipidaemia-related vascular calcification in vivo design with rats given a high-fat diet coupled with vitamin D3 plus nicotine, and palmitic acid (PA), the absolute most plentiful long-chain saturated fatty acid in plasma, ended up being utilized to cause lipid overbu
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