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Itaconic acid esters and hemiesters undergo Pd-catalyzed coupling reactions with arene diazonium salts in high to excellent yields. The coupling products of ortho-nitro arene diazonium salts can be converted in one or two steps to benzazepine-2-ones.In this paper, a molecularly imprinted two-dimensional photonic crystal hydrogel sensor (SMZ-MIPCH) for the sensitive and label-free recognition of sulfamethoxazole (SMZ) was prepared. The SMZ-MIPCH sensor response performance was investigated via measuring the diameter of the Debye ring (D