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05). However, SGLT2 inhibition when combined with dietary counselling led to greater loss of fat-free mass (counselling × medication interaction p = 0.047) and attenuated the rise in high-density lipoprotein cholesterol (counselling × medication interaction p = 0.028). In light of these data and the health implications of decreased fat-free mass, we recommend careful consideration before implementing SGLT2 inhibition as an adjunct to dietary counselling for weight loss in sedentary adults with obesity.Model membrane systems are essentia

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