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To explore the barriers to early diagnosis of HIV infection and timely initiation of antiretroviral therapy (ART). We assessed the annual number and proportion of ART-naïve people living with HIV infection (PLWH) with severe immunosuppression in Shenzhen, China, from 2008 to 2019. Selected ART-naïve PLWHs with severe immunosuppression who were seeking treatment for the first time in the hospital in 2019 were subjected to an in-depth interview. The proportion of severely immunosuppressed, ART-naïve PLWH decreased from 36.73% in 2008 to 8.94
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