https://www.selleckchem.com/products/rmc-6236.html
PBPK/PD models for 3 formulations of nifedipine were successfully established. The predicted maximum concentration (C ), area under plasma concentration-time curve (AUC), maximum reduction in SBP and area under effect-time curve were all within 0.5-2.0-fold of the observed data. Model simulations showed that the inhibitory effect of ritonavir on CYP3A4 increased the C of nifedipine 17.92-48.85-fold and the AUC 63.30-84.01-fold at steady state and decreased the SBP by 40 mmHg. Thus, the combination of nifedipine and ritonavir could
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