https://aminoacid-transport.co....m/index.php/the-effe
Mechanistically, CISH-/- iPSC-NK cells show enhanced metabolic fitness characterized by increased basal glycolysis, glycolytic ability, maximal mitochondrial respiration, ATP-linked respiration, and spare respiration capability mediated by mammalian target of rapamycin (mTOR) signaling that directly contributes to enhanced NK cell purpose. Together, these studies display that CIS plays a vital role to regulate person NK cellular metabolic activity and thereby modulate anti
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