https://www.selleckchem.com/pr....oducts/bicuculline.h
Together this suggests altered lactate metabolism and transport in cachexic livers, which may contribute to energetically inefficient inter-organ lactate cycling. Acyl-CoA synthetase-1 (ACSL1), known for activating long-chain fatty acids, was decreased in moderate and severe cachexia based on LC-MS/MS and immunoblotting. ACSL1 showed strong linear relationships with percent body weight change and muscle fiber size (R2=0.73-0.76, P less then 0.01). Mitochondrial coupling efficiency, which is compromised in cachexic livers to potentia
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