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77, 95% CI 0.50-1.17, p=.22). While the result showed that the prevalence of CRBSI with MCs was lower than that with PICCs (RR=0.55, 95% CI 0.33-0.92, p=.02) after poor-quality studies were removed. The sensitivity analysis shows that the results from this meta-analysis are fair in overall studies and non-poor-quality studies. All studies have no significant publication bias. This study provides the first systematic assessment of the risk of CRBSI between MCs and PICCs and provides evidence for the selection of appropriate vascular access