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In addition, Cur decreased the expression of Sp1, p65 and HSF1 by suppressing their transcription levels. Cur decreased NF-κB activity in OSCC cells, and Sp1 downregulation enhanced the effect of Cur. The findings from the present study suggested that Cur may inhibit the proliferation of OSCC cells via a Sp1/NF-κB-dependent mechanism.The present study reports on the case of a 50-year-old male with sinusitis, diplopia, secretory otitis media and skin eczema for 14 years. The patient presented with visual impairment in both eyes and su
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