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Together, these findings demonstrate that each EE variant causes a unique combination of defects in Kv7 channel function and neuronal expression, and suggest a critical need for both prediction algorithms and experimental interrogations to understand pathophysiology of Kv7-associated EE.Jazmurian playa was an ephemeral lake with a large catchment in southeast Iran, which dried up over the last 10 years as a result of prolonged drought. As the lake was recipient of incoming industrial water with trace metals deposited to the sediment, t
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