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Melasma severity and skin health were evaluated at 4 visits for each participant (baseline, weeks 4, 8, and 12, respectively). Severity of melasma scored by mMASI of the synbiotics group was 7.54±0.79, 7.36±0.80, 7.16±0.73, and 6.98±0.72 at baseline, weeks 4, 8, and 12, respectively, and 7.51±0.86, 7.52±0.88, 7.54±0.86, and 7.54±0.89 at baseline, weeks 4, 8, and 12, respectively, in the placebo group. Comparing between two groups at week 12, melasma score in the synbiotics supplement group was significantly lower than that in the placebo
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