https://www.selleckchem.com/pr....oducts/midostaurin-p
Glucocorticoids are widely used for therapy of hematological malignancies. Unfortunately, chronic treatment with glucocorticoids commonly leads to adverse effects including skin and muscle atrophy and osteoporosis. We found recently that REDD1 (regulated in development and DNA damage 1) plays central role in steroid atrophy. Here we tested whether REDD1 suppression makes glucocorticoid-based therapy of blood cancer safer. Unexpectedly, ~50% of top putative REDD1 inhibitors selected by bioinformatics screening of LINCS databas
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