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metabolic stress. Based on these data we conclude that RhoG-Rac1 signaling module plays critical regulatory roles in promoting mitochondrial dysfunction (caspase-3 activation) of the islet beta cell under metabolic stress. This systematic and meta-analysis review was conducted to determine the status of Iranian children and adolescents' physical activity. All the related articles which were published inthe major databases, including Pubmed, Scopus, Web ofScience, Embase, Magiran, SID from the beginning of 2010tothe end of 2019, were re
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