https://www.selleckchem.com/pr....oducts/l-kynurenine.
The median delay between anti-TNFα start and NAE occurrence was 6 months (range 13 days to 26 months). In 10 of 17 patients, anti-TNFα antibodies were stopped. Nine of 17 patients had a complete resolution (including 2 severe NAE) and 8 of 17 a partial resolution (including 6 severe NAE). We estimate the incidence of severe NAE in pediatric IBD treated with anti-TNFα antibodies at 1 case for 10,000 patients-year in France. Conclusions NAE associated with anti-TNFα antibodies in pediatric IBD are rare. In severe NAE, we recommend to
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