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NIC offspring from both sexes didn't show variations in hypothalamic ECS markers. Peripheral ECS markers showed no modifications in NIC males. On the other hand, NIC females had lower liver DAGL and CB1, higher VAT DAGL, higher adrenal NAPE-PLD and higher thyroid FAAH. Endocannabinoids biosynthesis ended up being suffering from smoking visibility during nursing only in females; modifications in peripheral areas advise reduced activity in liver and higher activity in VAT, adr