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subjects with type 2 diabetes, differentiating LADY from phenotypic type 2 diabetes subjects is important. A high GADA positivity was observed in youth-onset type 2 diabetes subjects in China. As subjects with LADY had an increased susceptible HLA genetic load and different cytokine levels compared with subjects with type 2 diabetes, differentiating LADY from phenotypic type 2 diabetes subjects is important. Use of systematic reviews (SRs) as first-level evidence for guideline recommendations hinges on review quality. In particular, U