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Gene database searches identified DHDH homologues (with 95% amino acid sequence identity) in humans and apes. Thus, DHDH acts as an efficient AF reductase in primates. Gastric cancer (GC) remains a serious threat to human health with a high cancer-related death rate and unsatisfactory treatment effects after curative resection, especially with advanced GC. Thus, exploration of the molecular mechanism of cisplatin (CDDP) resistance in GC is crucial. circCCDC66 (hsa_circ_0001313) expression was detected by quantitative reverse-transcr