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Medications For ADHD The most frequently prescribed medication for ADHD is stimulants. They are effective in improving attention and reduce impulsivity and hyperactivity. They can also cause side effects like stomach upset, headaches as well as changes in blood pressure and heart rate. Most stimulants belong to two classes of drugs: methylphenidates as well as amphetamines. They are available in liquid and chewable forms and are available in short-acting and intermediate- or long-acting