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The liver triglyceride content was higher in female, and tended to be higher in male (P less then 0.05), HFA offspring than CN offspring (P less then 0.05). The liver mRNA expression of fat synthesis genes, such as Pparγ2 (male and female) and Cidec (male), was higher in HFA than CN offspring (P less then 0.05). Conclusion Excessive maternal supplementation of FA in mice leads to lower insulin synthesis and an impairment in hepatic fat metabolism in the offspring. © 2020 The Author(s).The development of multi-resistant strains of plasmo
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