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Whereas TiO NP with cisplatin improves chemotherapy response in both in vitro and in vivo melanoma models. In addition, autophagy plays a vital part during sensitizing melanoma cells to chemotherapy.The mixture of TiO2 NP with cisplatin enhances chemotherapy response in both in vitro plus in vivo melanoma designs. In inclusion, autophagy plays a vital role during sensitizing melanoma cells to chemotherapy.Twelve Kunming mice were ra