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The aim of this research was to research the role of prazosin treatment on behavioral parameters (freezing time, total transitions, and rearing frequency calculated from the open field; anxiety index, complete entries and time spent in open hands calculated through the elevated plus maze), apoptotic proteins and α-2c-AR in anxiety memory reconsolidation in the PSI anxiety rat model. We utilized western blot evaluation to look for the effectation of prazosin (0.5 mg/kg/ip) on α-2c-AR and