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5, p 0.04). Major non-fatal adverse events were associated with age (HR 1.4, p 0.022). New episodes of infection were correlated with S aureus infection (HR 4.8, p 0.001), right-sided endocarditis (HR 7.4, p 0.001), spondylodiscitis (HR 6.8, p 0.004) and intravenous drug abuse (HR 10.3, p 0.001). After multivariate analysis, only drug abuse was an independent predictor of new episodes of endocarditis (HR 8.5, p 0.001). Echocardiographic follow-up, available in 95 cases, showed a worsening of left ventr