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correlated with the EMT gene levels. Circ-10720 regulates EMT, apoptosis and proliferation and acts as a biomarker of relapse in NSCLC. Circ-10720 regulates EMT, apoptosis and proliferation and acts as a biomarker of relapse in NSCLC. The extent of inter- and intratumoral genomic heterogeneity and the clonal evolution of metastatic squamous cell carcinoma of the lung (LUSC) are poorly understood. Genomic studies of LUSC are challenged by their low tumor cell content. We sought to define the genomic landscape and evolutionary trajectorie