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This study aimed to investigate the associations of leukocyte count with the risks of stroke and coronary heart disease among the general Japanese population. A total of 5,242 residents aged 40-69 years living in two Japanese communities underwent leukocyte count measurements between 1991 and 2000, and the data were updated using 5- or 10-year follow-ups or both. Participants who had histories of stroke, coronary heart disease, or high values of leukocyte count (>130×10 cells/mm ) were excluded. Hazard ratios with 95% confidence interva