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ADHD Medication - Finding the Right One Finding the best ADHD medication requires a lot of trial and error. is affected by many factors that include metabolism, side effects, and how a medication interacts with other medications and supplements. It can take some time for stimulants to take effect, but they improve attention, focus, and impulsivity. They also increase brain chemical such as dopamine and adrenaline. Stimulants Stimulants are also referred to as uppers. They speed up the body's functions and make yo