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Depolarizing GABA actions are essential for neurogenesis, differentiation, migration, and synaptogenesis. Furthermore, the conversion of GABA answers from inhibition to excitation could be induced in adults by pathological circumstances. Because GABAA receptors tend to be Cl- stations, alternating GABA activities between hyperpolarization (Cl- influx) and depolarization (Cl- efflux) are induced by alterations in the Cl- gradient, which can be controlled by Cl- transport