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The optimum formula was characterized, and their morphological and antifungal task were examined. Different ophthalmic formulations laden with the optimized vesicles were prepared and characterized. The ocular irritation as well as in vivo corneal permeation had been investigated. Results revealed that the drug-to-phospholipid-molar ratio, the percentage of advantage activator, the portion of ethanol, plus the percentage of stearyl amine significantly impact the attributes of the vesicles. The optimized