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ADHD Medications - Stimulant Or Non Stimulant? Stimulant drugs are the most popular ADHD treatment, because they are the most researched and have a fast-acting effect. However, they aren't for everyone. increase the communication between nerves and the regions of the brain, thereby reducing symptoms of ADHD. They can also have side effects like an appetite loss and changes in heart rate or blood pressure. Stimulants The