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DFCR is active as preliminary therapy of more youthful CLL clients. Immune-mediated and infectious toxicities took place and required active management.We assessed the epidemiologic progress against youth and adolescent severe lymphoblastic leukaemia (ALL) into the Netherlands over a 26 12 months period. each patients less then 18 many years had been selected from the Netherlands Cancer Registry additionally the Dutch Childhood Oncology Group. Trend analyses were performed as