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to alleviate constipation symptoms and reduce medication requirements in patients with advanced CKD. Baloxavir acid, the active form of the orally available prodrug baloxavir marboxil, is a novel cap-dependent endonuclease inhibitor of influenza virus. #link# Baloxavir marboxil has been shown to rapidly reduce virus titres compared with oseltamivir in clinical studies. We investigated the relationship between pharmacokinetic (PK) parameters and antiviral activity of baloxavir acid based on virus titre reduction in lungs of infected mice