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An overall total of 19 key questions (12 for maternal serum and 7 for cfDNA evaluating) had been defined. The main recommendations are 1) women that are pregnant should really be informed of typical fetal aneuploidy which can be recognized, dangers for chromosomal problem in line with the maternal age, recognition price and false positive rate for common fetal aneuploidy with each testing test, limits, as well as the advantages and dangers of unpleasant diagnostic evaluation, 2)