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043), and sleep disorders (OR 1.677, 95% CI 1.472-1.91 were presented to be associated with an increased risk of stroke after correcting all the confounders. The logistic regression analysis showed that there was a synergic, additive interaction between depression and sleep disorders on the stroke occurrence, and the proportion of stroke patients caused by this interaction accounted for 27.1% of all the stroke patients. Depression, depression severity, and sleep disorders are all independently associated with a high risk of stroke. The