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Conclusions Urine Klotho/creatinine levels had been somewhat lower and serum intact fibroblast development factor-23 levels had been substantially higher in critically sick patients with acute kidney injury versus paired controls without acute kidney injury. Whenever assessed in the first 48 hours of ICU admission or severe renal damage diagnosis, urine Klotho/creatinine independently related to significant adverse kidney activities, particularly in patients with intense kidney damage. Thes
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